TMEM201 Gene Summary [Human]
Predicted to enable actin filament binding activity and lamin binding activity. Involved in centrosome localization; nuclear envelope organization; and protein localization to nuclear envelope. Located in nuclear envelope. Is integral component of nuclear inner membrane. Colocalizes with cortical endoplasmic reticulum and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMEM201 |
| Official Name | transmembrane protein 201 [Source:HGNC Symbol;Acc:HGNC:33719] |
| Ensembl ID | ENSG00000188807 |
| Bio databases IDs | |
| Aliases | transmembrane protein 201, spindle associated membrane protein 1 |
| Synonyms | D4Ertd429e, Ima1, NET5, RGD1306651, RP13-15M17.2, SAMP1, transmembrane protein 201 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM201 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Protein of unknown function C-terminus (DUF2448)
- lamin binding
- protein binding
- Ima1 N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- organismal death
- metastasis
- rotator cuff injury
- major depression
- Alzheimer disease
regulated by
- metformin
role in cell
- phosphorylation in
- migration
- invasion by
- signaling in
- localization
- organization
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cortical endoplasmic reticulum
- centrosome
- inner nuclear membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM201 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear migration along microtubule
- fibroblast migration
Cellular Component
Where in the cell the gene product is active
- nuclear inner membrane
- nuclear membrane
- cytoplasm
- spindle pole
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- lamin binding