HOTAIR Gene Summary [Human]
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | HOTAIR |
| Official Name | HOX transcript antisense RNA [Source:HGNC Symbol;Acc:HGNC:33510] |
| Ensembl ID | ENSG00000228630 |
| Bio databases IDs | |
| Aliases | HOX transcript antisense RNA, HOXC cluster antisense RNA 4 (non-protein coding), non-protein coding RNA 72 |
| Synonyms | FLJ41747, Gm16258, HOXAS, HOXC11-AS1, HOXC-AS4, HOX transcript antisense RNA, HOX transcript antisense RNA (non-protein coding), NCRNA00072 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOTAIR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- metastasis
- gastric carcinoma
- gastric epithelial cancer
- metastatic breast cancer
- hepatic fibrosis
- carbon tetrachloride-induced liver fibrosis
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- growth
- cell viability
- expression in
- migration
- proliferation
- apoptosis
- phosphorylation in
- accumulation in
- cell death
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome