NPLOC4 Gene Summary [Human]
Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NPLOC4 |
| Official Name | NPL4 homolog, ubiquitin recognition factor [Source:HGNC Symbol;Acc:HGNC:18261] |
| Ensembl ID | ENSG00000182446 |
| Bio databases IDs | |
| Aliases | NPL4 homolog, ubiquitin recognition factor |
| Synonyms | mKIAA1499, NPL4, NPL4 homolog, ubiquitin recognition factor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPLOC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- NPL4 family
- ATPase binding
- Mpr1p, Pad1p N-terminal (MPN) domains
- binding protein
- Zn-finger in Ran binding protein and others
- NPL4 family, putative zinc binding region
- Ubl1_cv_Nsp3_N-like
- ubiquitin binding
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- age-related hearing loss
- progressive vision loss
- cataract
- myopia
- astigmatism
- refractive error
- non-melanoma skin cancer
- strabismus
- amblyopia
role in cell
- expression in
- accumulation in
- degradation in
- signaling in
- organization
- K11 polyubiquitination in
- processing in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endoplasmic reticulum mitochondria contact site
- endomembrane system
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPLOC4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- proteasomal ubiquitin-dependent protein catabolic process
- Golgi organization
- retrograde protein transport, ER to cytosol
- negative regulation of RIG-I signaling pathway
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear outer membrane-endoplasmic reticulum membrane network
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding
- K63-linked polyubiquitin binding
- metal ion binding
- ATPase binding