NSFL1C Gene Summary [Human]
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]
Details
| Type | Processed Transcript |
| Official Symbol | NSFL1C |
| Official Name | NSFL1 cofactor [Source:HGNC Symbol;Acc:HGNC:15912] |
| Ensembl ID | ENSG00000088833 |
| Bio databases IDs | |
| Aliases | NSFL1 cofactor, SHP1 homolog (S. cerevisiae), UBX domain protein 2C |
| Synonyms | dJ776F14.1, FLJ13523, Munc-18c, NSFL1 cofactor, Nsfl1 Cofactor P47, NSFL1 (p97) cofactor (p47), P47, Stxbp3a, T-snare, UBX1, UBXD10, UBXN2C, XY40 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NSFL1C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- SEP domain
- phospholipid binding
- ATPase binding
- UBA-like domain
- Ubl1_cv_Nsp3_N-like
- ubiquitin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- Nucleus
- centrosome
- Golgi Apparatus
- cytosol
- chromosome
- coiled body
- synaptic vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NSFL1C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- establishment of mitotic spindle orientation
- proteasomal ubiquitin-dependent protein catabolic process
- membrane fusion
- Golgi organization
- nuclear envelope reassembly
- positive regulation of mitotic centrosome separation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- chromosome
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- lipid binding