TRIM14 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | TRIM14 |
| Official Name | tripartite motif containing 14 [Source:HGNC Symbol;Acc:HGNC:16283] |
| Ensembl ID | ENSG00000106785 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 14 |
| Synonyms | 5830400N10Rik, pub, tripartite motif-containing 14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- transcription co-activator
- SPRY domain
- B-box zinc finger
- enzyme
- protein binding
- associated with SPRY domains
- SPRY-associated domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- systemic lupus erythematosus
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- organismal death
- peripheral arterial disease
- multiple sclerosis
- idiopathic inflammatory myopathy
- polyglandular autoimmune syndrome type 1
role in cell
- expression in
- apoptosis
- invasion by
- proliferation
- migration
- phosphorylation in
- replication
- replication in
- cisplatin sensitivity
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- protein ubiquitination
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- phagocytic vesicle
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription coactivator activity
- binding, bridging