PIBF1 Gene Summary [Human]
This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | PIBF1 |
| Official Name | progesterone immunomodulatory binding factor 1 [Source:HGNC Symbol;Acc:HGNC:23352] |
| Ensembl ID | ENSG00000083535 |
| Bio databases IDs | |
| Aliases | progesterone immunomodulatory binding factor 1, progesterone-induced blocking factor 1 |
| Synonyms | 4930513H15Rik, C13orf24, CEP90, D14ERTD581E, JBTS33, PIBF, progesterone immunomodulatory binding factor 1, RGD1305077 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIBF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-4 receptor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Joubert syndrome type 1
- pulmonary emphysema
- Joubert syndrome type 33
- Dandy-Walker syndrome
- ciliopathy
- hereditary disorder
- gout
- premature labor
- preterm birth
- Joubert syndrome
role in cell
- fragmentation
- assembly
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centriolar satellite
- Cytoplasm
- Extracellular Space
- basal bodies
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIBF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of Janus kinase activity
- cilium morphogenesis
- negative regulation of prostaglandin biosynthetic process
- positive regulation of tyrosine phosphorylation of STAT protein
- negative regulation of tyrosine phosphorylation of STAT protein
- immune system process
- negative regulation of natural killer cell activation
- negative regulation of interleukin-12 production
- positive regulation of interleukin-10 production
- protein localization to centrosome
- mitotic metaphase plate congression
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- extracellular space
- cytoplasm
- centriolar satellite
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-4 receptor binding