EPGN Gene Summary [Human]
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | EPGN |
| Official Name | epithelial mitogen [Source:HGNC Symbol;Acc:HGNC:17470] |
| Ensembl ID | ENSG00000182585 |
| Bio databases IDs | |
| Aliases | epithelial mitogen, epigen |
| Synonyms | 2310069M11Rik, ALGV3072, EPG, Epigen, epithelial mitogen, PRO9904, RGD1560084 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EPGN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane receptor protein tyrosine kinase activator
- epidermal growth factor receptor binding
- receptor agonist activity
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endocytic vesicle membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EPGN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- angiogenesis
- epidermal growth factor receptor signaling pathway
- positive regulation of cell proliferation
- positive regulation of mitosis
- positive regulation of MAPK cascade
- positive regulation of epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- clathrin-coated endocytic vesicle membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- epidermal growth factor receptor binding
- transmembrane receptor protein tyrosine kinase activator activity