SLC25A21 Gene Summary [Human]
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
Details
| Type | Protein Coding |
| Official Symbol | SLC25A21 |
| Official Name | solute carrier family 25 member 21 [Source:HGNC Symbol;Acc:HGNC:14411] |
| Ensembl ID | ENSG00000183032 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 member 21 |
| Synonyms | 9930033G19Rik, A630030I10, MTDPS18, ODC, ODC1, solute carrier family 25 member 21, solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC25A21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitochondrial carrier protein
- alpha-ketoglutarate transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- colorectal cancer
- breast carcinoma
- mitochondrial DNA depletion syndrome 18
- prostatic carcinoma
- KRAS mutation positive colorectal cancer
- hearing loss
- disorder of pregnancy
- organismal death
regulates
- 2-oxoglutaric acid
- 2-oxoadipic acid
- pimelic acid
- glutaric acid
- magnesium
- L-lysine
- oxalacetic acid
- adipic acid
- mineral
- 2-aminoadipic acid
role in cell
- invasion by
- cetuximab resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC25A21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid transport
- lysine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- antiporter activity
- alpha-ketoglutarate transmembrane transporter activity