DDX41 Gene Summary [Human]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD box protein family and interacts with several spliceosomal proteins. In addition, the encoded protein may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. [provided by RefSeq, Jan 2017]
Details
| Type | Retained Intron |
| Official Symbol | DDX41 |
| Official Name | DEAD-box helicase 41 [Source:HGNC Symbol;Acc:HGNC:18674] |
| Ensembl ID | ENSG00000183258 |
| Bio databases IDs | |
| Aliases | DEAD-box helicase 41, Abstrakt |
| Synonyms | 2900024F02Rik, AA958953, ABS, DEAD-box helicase 41, LOC100910720, MPLPF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX41 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- RNA helicase
- DNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- lymphatic neoplasia
- hematological neoplasia
- liver cancer
- acute myeloid leukemia
- aplastic anemia
- myelodysplastic syndrome
- mixed phenotype acute leukemia
- myeloid neoplasm
- myeloid neoplasia
role in cell
- differentiation
- production in
- cell death
- proliferation
- formation
- apoptosis
- processing in
- formation in
- replication in
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Endoplasmic Reticulum
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX41 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- apoptotic process
- cell differentiation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- cytosol
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity
- metal ion binding
- mRNA binding