Ddx41 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within cellular response to interferon-beta; defense response to virus; and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum and nucleus. Is expressed in hippocampus; pancreas; and testis. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddx41 |
| Official Name | DEAD box helicase 41 [Source:MGI Symbol;Acc:MGI:1920185] |
| Ensembl ID | ENSMUSG00000021494 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 41 |
| Synonyms | 2900024F02Rik, AA958953, ABS, DEAD-box helicase 41, LOC100910720, MPLPF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx41 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- RNA helicase
- DNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- lymphatic neoplasia
- hematological neoplasia
- liver cancer
- acute myeloid leukemia
- aplastic anemia
- myelodysplastic syndrome
- mixed phenotype acute leukemia
- myeloid neoplasm
- myeloid neoplasia
role in cell
- differentiation
- production in
- cell death
- proliferation
- formation
- apoptosis
- processing in
- formation in
- replication in
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Endoplasmic Reticulum
- cytosol
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx41 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- apoptotic process
- cell differentiation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- membrane
- cytosol
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity
- metal ion binding
- mRNA binding