PKN2 Gene Summary [Human]
Enables RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apical junction assembly; positive regulation of cell cycle; and positive regulation of viral genome replication. Located in several cellular components, including cleavage furrow; cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PKN2 |
| Official Name | protein kinase N2 [Source:HGNC Symbol;Acc:HGNC:9406] |
| Ensembl ID | ENSG00000065243 |
| Bio databases IDs | |
| Aliases | protein kinase N2, cardiolipin-activated protein kinase Pak2 |
| Synonyms | 6030436C20RIK, PAK-2, PRK2, PRKCL2, PRO2042, protein kinase N2, STK7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein kinase C terminal domain
- Protein tyrosine and serine/threonine kinase
- serine/threonine kinase domain
- enzyme binding
- central domain
- histone deacetylase binding
- coiled-coil domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- activation loop
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
- Hr1 repeat
- C2 domain
- HR1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- chronic obstructive pulmonary disease
- locally advanced prostate cancer
- prostate cancer
- scleroderma
- ST-elevation myocardial infarction
- productive infection by HIV-1
role in cell
- apoptosis
- phosphorylation in
- formation
- formation in
- differentiation
- adhesion
- maturation
- cytokinesis
- Clathrin mediated endocytosis by
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intermediate filament cytoskeleton
- cell surface
- perinuclear region
- Nucleus
- Plasma Membrane
- centrosome
- midbody
- intercellular junctions
- cytosol
- nucleoplasm
- nuclear bodies
- cleavage furrow
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell projection organization
- cell adhesion
- protein phosphorylation
- positive regulation of mitotic cell cycle
- cell division
- apical junction assembly
- apoptotic process
- regulation of cell motility
- positive regulation of viral genome replication
- peptidyl-serine phosphorylation
- positive regulation of cytokinesis
- intracellular signal transduction
- epithelial cell migration
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cleavage furrow
- plasma membrane
- nucleoplasm
- nucleus
- centrosome
- perinuclear region of cytoplasm
- intermediate filament cytoskeleton
- cytoplasm
- apical junction complex
- cytosol
- macromolecular complex
- midbody
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- ATP binding
- RNA binding
- protein binding
- histone deacetylase binding
- cadherin binding
- small GTPase binding
- protein kinase activity
- protein serine/threonine kinase activity
- kinase activity
- protein kinase C activity