PLCB1 Gene Summary [Human]
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PLCB1 |
| Official Name | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] |
| Ensembl ID | ENSG00000182621 |
| Bio databases IDs | |
| Aliases | phospholipase C beta 1, phosphoinositide phospholipase C |
| Synonyms | 3110043I21Rik, DEE12, EIEE12, LOC688139, mKIAA0581, Phosphb, Phosphoinositidase C, phospholipase C beta 1, phospholipase C, beta 1, Phospholipase c beta 1b, phospholipase C β 1, phospholipase C, β 1, Phospholipase c β 1b, PIC beta1, PI-PLC, PLC'1, PLC-154, Plcb, PLCB1A, PLCB1B, Plc Beta, PLC-beta-1, PLC-I, Plc β, PLC-β-1, RATPHOSPHB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLCB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- GTPase activator
- enzyme
- identical protein binding
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- P-box
- Phospholipase C, catalytic domain (part: domain X)
- phosphatidylinositol-4,5-bisphosphate binding
- Phospholipase C, catalytic domain (part: domain Y)
- PH domain
- tail domain
- C2 domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- calmodulin binding
- lamin binding
- enzyme binding
- calcium ion binding
- phospholipase C
- protein binding
- phosphoinositide-specific phospholipase C-like phosphodiesterase catalytic domain
- Pleckstrin homology-like domain
- PLC-beta C terminal
- G-box domain
- Protein of unknown function (DUF1154)
- phosphoinositide phospholipase C
- Phosphoinositide-specific phospholipase C, efhand-like
- PDZ binding motif
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the PLCB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Antioxidant Action of Vitamin C
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac Hypertrophy Signaling
- CCR3 Signaling in Eosinophils
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Dendritic Cell Maturation
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- fMLP Signaling in Neutrophils
- Gαq Signaling
- Leptin Signaling in Obesity
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Role of Tissue Factor in Cancer
- Sphingosine-1-phosphate Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- COVID-19
- epithelial cancer
- liver cancer
- kidney stones
- obstructive sleep apnea
- seizures
- early infantile epileptic encephalopathy type 12
- myotonic dystrophy type 2
role in cell
- activation in
- expression in
- G2/M phase transition
- morphology
- cell death
- phosphorylation in
- differentiation
- fusion
- activation
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- myelin enriched fraction
- membrane fraction
- glutaminergic synapse
- intracellular space
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- cell-cell contacts
- cytosol
- plasma membrane extracellular face
- caveolar membranes
- basolateral membrane
- nucleoplasm
- nuclear envelope
- nuclear speckles
- zymogen granules
- synapse
- sarcolemma
- transverse tubules
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLCB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of CD24 biosynthetic process
- regulation of fertilization
- phosphatidylinositol catabolic process
- G-protein coupled acetylcholine receptor signaling pathway
- positive regulation of myoblast differentiation
- fat cell differentiation
- learning
- activation of meiosis involved in egg activation
- positive regulation of embryonic development
- memory
- positive regulation of developmental growth
- glutamate receptor signaling pathway
- negative regulation of monocyte extravasation
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- G2/M transition of mitotic cell cycle
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of insulin secretion
- release of sequestered calcium ion into cytosol
- positive regulation of G1/S transition of mitotic cell cycle
- G-protein coupled receptor signaling pathway
- signal transduction
- insulin-like growth factor receptor signaling pathway
- phosphatidylinositol metabolic process
- cerebral cortex development
- regulation of G-protein coupled receptor protein signaling pathway
- inositol trisphosphate metabolic process
- positive regulation of interleukin-12 production
- phosphatidylinositol-mediated signaling
- positive regulation of JNK cascade
- interleukin-15-mediated signaling pathway
- positive regulation of acrosome reaction
- interleukin-1-mediated signaling pathway
- interleukin-12-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- nuclear speck
- cytosol
- chromatin
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylinositol phospholipase C activity
- calmodulin binding
- identical protein binding
- protein binding
- phospholipase C activity
- calcium ion binding
- GTPase activator activity
- lamin binding
- enzyme binding