PPME1 Gene Summary [Human]
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Details
| Type | Processed Transcript |
| Official Symbol | PPME1 |
| Official Name | protein phosphatase methylesterase 1 [Source:HGNC Symbol;Acc:HGNC:30178] |
| Ensembl ID | ENSG00000214517 |
| Bio databases IDs | |
| Aliases | protein phosphatase methylesterase 1 |
| Synonyms | 1110069N17Rik, 2700017M01Rik, ABDH19, PME-1, protein phosphatase methylesterase 1, RGD1309683 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPME1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- protein phosphatase inhibitor activity
- alpha/beta hydrolase fold
- protein kinase binding
- alpha/beta hydrolases
- Alpha/beta hydrolase family
- protein phosphatase binding
- protein phosphatase regulator
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- psoriasis
- astrocytoma
- glioma formation
- cognitive impairment
role in cell
- phosphorylation in
- phagocytosis by
- dephosphorylation in
- G2/M phase transition
- long-term potentiation in
- capivasertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPME1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G2/M transition of mitotic cell cycle
- protein demethylation
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein phosphatase inhibitor activity
- protein phosphatase binding
- protein binding
- cadherin binding
- protein methylesterase activity
- protein phosphatase 2A binding
- protein phosphatase regulator activity
- protein C-terminal methylesterase activity