PLEKHG4B Gene Summary [Human]
This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | PLEKHG4B |
| Official Name | pleckstrin homology and RhoGEF domain containing G4B [Source:HGNC Symbol;Acc:HGNC:29399] |
| Ensembl ID | ENSG00000153404 |
| Bio databases IDs | |
| Aliases | pleckstrin homology and RhoGEF domain containing G4B |
| Synonyms | ARHGEF48, pleckstrin homology and RhoGEF domain containing G4B |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLEKHG4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- intercellular junctions
- cytosol
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLEKHG4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- axon guidance
Cellular Component
Where in the cell the gene product is active
- nucleus
- basal plasma membrane
- cell-cell junction
- cytoplasm
- cytosol
- extrinsic to membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity