HAVCR1 Gene Summary [Human]
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]
Details
| Type | Protein Coding |
| Official Symbol | HAVCR1 |
| Official Name | hepatitis A virus cellular receptor 1 [Source:HGNC Symbol;Acc:HGNC:17866] |
| Ensembl ID | ENSG00000113249 |
| Bio databases IDs | |
| Aliases | hepatitis A virus cellular receptor 1, T-cell immunoglobulin mucin family member 1, kidney injury molecule 1 |
| Synonyms | AI503787, CD365, HAVCR, hepatitis A virus cellular receptor 1, HKIM-1, Kidney Injury Molecule-1, KIM-1, T-cell immunoglobulin and mucin domain protein 1, TIM, TIM-1, TIMD-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HAVCR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin variable domain
- viral receptor
- Immunoglobulin V-Type
- immunoglobulin domain
- ectodomain
- Immunoglobulin like
- immunoglobulin variable region-like domain
- mucin domain
- protein binding
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the HAVCR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- proteinuria
- hypertension
- systemic lupus erythematosus
- hyperplasia
- atopic disease
- atopic dermatitis
- ulcerative colitis
- anti-thymocyte serum nephritis
role in cell
- activation
- production in
- cellular infiltration by
- proliferation
- phosphorylation in
- expression in
- differentiation
- quantity
- apoptosis
- Gap 0-Gap 1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- motile cilia
- cilia
- cell surface
- membrane surface
- cellular membrane
- apical cell surfaces
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HAVCR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- phagocytosis, engulfment
- positive regulation of mast cell activation
Cellular Component
Where in the cell the gene product is active
- motile cilium
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein binding
- viral receptor activity