TFDP3 Gene Summary [Human]
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.[provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | TFDP3 |
| Official Name | transcription factor Dp family member 3 [Source:HGNC Symbol;Acc:HGNC:24603] |
| Ensembl ID | ENSG00000183434 |
| Bio databases IDs | |
| Aliases | transcription factor Dp family member 3, E2F-like protein, cancer/testis antigen 30 |
| Synonyms | CT30, DP4, E2F-like, HCA661, transcription factor Dp family member 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFDP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Dimerization domain of DP
- DNA binding domain
- transcription factor binding
- E2F/DP family winged-helix DNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TFDP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of sequence-specific DNA binding transcription factor activity
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity