SNRPA Gene Summary [Human]
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | SNRPA |
| Official Name | small nuclear ribonucleoprotein polypeptide A [Source:HGNC Symbol;Acc:HGNC:11151] |
| Ensembl ID | ENSG00000077312 |
| Bio databases IDs | |
| Aliases | small nuclear ribonucleoprotein polypeptide A |
| Synonyms | C430021M15RIK, Mud1, Rnu1a-1, small nuclear ribonucleoprotein polypeptide A, U1-A, U1 SNRNP-SPECIFIC protein A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNRPA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- U1 snRNA binding
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- nuclear localization sequence
- ribonucleoprotein binding
- protein binding
- identical protein binding
- DNA binding
- RNA binding
Pathways
Biological processes and signaling networks where the SNRPA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- stomach disorder
- Alzheimer disease
- spliceosomepathy
- infection by HIV-1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNRPA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- U4/U6 x U5 tri-snRNP complex
- spliceosomal complex
- U1 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- RNA binding
- U1 snRNA binding