PGP Gene Summary [Human]
Enables glycerol-3-phosphatase activity and phosphoglycolate phosphatase activity. Involved in glycerol biosynthetic process; glycerophospholipid metabolic process; and negative regulation of gluconeogenesis. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PGP |
| Official Name | phosphoglycolate phosphatase [Source:HGNC Symbol;Acc:HGNC:8909] |
| Ensembl ID | ENSG00000184207 |
| Bio databases IDs | |
| Aliases | phosphoglycolate phosphatase |
| Synonyms | 1700012G19Rik, AUM, G3PP, PGPase, phosphoglycolate phosphatase, RGD1307773 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PGP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoglycolate/pyridoxal phosphate phosphatase family
- protein-tyrosine-phoshatase
- phosphoglycolate phosphatase
- HAD-superfamily class IIA hydrolase, TIGR01459
- enzyme
- magnesium ion binding
- HAD-superfamily subfamily IIA hydrolase, TIGR01457
- Haloacid Dehalogenase Superfamily Class (subfamily) IIA
- HAD-hyrolase-like
- apyrase
- phosphatase
- HAD-superfamily subfamily IIA hydrolase, TIGR01458
- Haloacid Dehalogenase-like Hydrolases
- HAD-superfamily class IIA hydrolase, TIGR01456, CECR5
- haloacid dehalogenase-like hydrolase
Pathways
Biological processes and signaling networks where the PGP gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PGP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gluconeogenesis
- glycerophospholipid metabolic process
- glycerol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- glycerol-1-phosphatase activity
- phosphoglycolate phosphatase activity
- adenosine-diphosphatase activity
- protein tyrosine phosphatase activity
- glycerol-3-phosphatase activity