PPP3CA Gene Summary [Human]
Enables several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; peptidyl-serine dephosphorylation; and response to calcium ion. Located in several cellular components, including cytosol; dendritic spine; and nucleoplasm. Part of calcineurin complex. Colocalizes with cytoplasmic side of plasma membrane. Implicated in developmental and epileptic encephalopathy 91. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPP3CA |
| Official Name | protein phosphatase 3 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9314] |
| Ensembl ID | ENSG00000138814 |
| Bio databases IDs | |
| Aliases | protein phosphatase 3 catalytic subunit alpha, calcineurin A alpha, protein phosphatase 2B, catalytic subunit, alpha isoform |
| Synonyms | 2900074D19Rik, ACCIID, Calcineurin, Calcineurin A Alpha, Calcineurin A α, CALN, CALNA, CALNA1, CCN1, CN, CnA, CNA1, CnA-α, DEE91, IECEE, IECEE1, PP2BA, PP2B-A alpha, PP2B-A α, Pp2b Subunit A, PPP2B, PPP3CA alpha isoform, PPP3CA α isoform, protein phosphatase 3 catalytic subunit alpha, protein phosphatase 3, catalytic subunit, alpha isoform, protein phosphatase 3 catalytic subunit α, protein phosphatase 3, catalytic subunit, α isoform |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP3CA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- autoinhibitory protein domain
- calmodulin binding
- catalytic domain
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- calmodulin binding domain
- cyclosporin A binding
- enzyme binding
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- Calcineurin-like phosphoesterase
- ATPase binding
- binding protein
- protein phosphatase
- calcium-dependent protein serine/threonine phosphatase
- phosphatase
- Protein phosphatase 2A homologues, catalytic domain
- calcineurin B binding domain
Pathways
Biological processes and signaling networks where the PPP3CA gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Autophagy
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
- breast cancer
- osteoarthritis
- insomnia
- prostate cancer
- heart failure
- diffuse large B-cell lymphoma
- acute renal allograft rejection
- post transplant diabetes mellitus
- acute generalized exanthematous pustulosis
role in cell
- apoptosis
- expression in
- adhesion
- cell death
- phosphorylation in
- activation
- degradation in
- differentiation
- proliferation
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- Plasma Membrane
- Mitochondria
- intercellular junctions
- cytosol
- cytoplasmic face of plasma membrane
- apical membrane
- basal membrane
- lateral plasma membrane
- nucleoplasm
- nuclear bodies
- dendritic spines
- synaptic vesicles
- synapse
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP3CA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transition between fast and slow fiber
- positive regulation of endocytosis
- T cell activation
- epidermis development
- negative regulation of insulin secretion
- positive regulation of cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of glomerulus development
- dendrite morphogenesis
- skeletal muscle tissue regeneration
- positive regulation of saliva secretion
- peptidyl-serine dephosphorylation
- negative regulation of dendrite morphogenesis
- wound healing
- positive regulation of osteoclast differentiation
- skeletal muscle fiber development
- cellular response to glucose stimulus
- renal filtration
- G1/S transition of mitotic cell cycle
- calcium ion transport
- multicellular organismal response to stress
- positive regulation of calcineurin-NFAT signaling cascade
- dephosphorylation
- cardiac muscle hypertrophy in response to stress
- calcineurin-NFAT signaling cascade
- regulation of excitatory postsynaptic membrane potential
- protein dephosphorylation
- positive regulation of activated T cell proliferation
- regulation of cell proliferation involved in kidney morphogenesis
- keratinocyte differentiation
- negative regulation of gene expression
- negative regulation of signaling
- response to amphetamine
- response to calcium ion
- protein import into nucleus
- positive regulation of gene expression
- regulation of synaptic transmission
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- slit diaphragm
- protein serine/threonine phosphatase complex
- plasma membrane
- internal side of plasma membrane
- nucleoplasm
- Z disc
- calcineurin complex
- cytoplasm
- sarcolemma
- mitochondrion
- dendritic spine
- cytosol
- extrinsic to plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- cyclosporin A binding
- calmodulin binding
- protein binding
- calmodulin-dependent protein phosphatase activity
- calcium ion binding
- protein dimerization activity
- ATPase binding
- myosin phosphatase activity
- enzyme binding