CAPN8
CAPN8 Gene Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity and identical protein binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within calcium-dependent self proteolysis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | CAPN8 |
| Official Name | calpain 8 [Source:HGNC Symbol;Acc:HGNC:1485] |
| Ensembl ID | ENSG00000203697 |
| Bio databases IDs | |
| Aliases | calpain 8 |
| Synonyms | calpain 8,CL-2',Cls4,LOC644151,nCL-2,nCL-2' |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- The penta-EF hand (PEF) family
- EF-Hand
- Calpain family cysteine protease
- calpain
- peptidase
- EFh
- Calpain_III
- CysPc
- identical protein binding
Pathways
Biological processes and signaling networks where the CAPN8 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CCDC18
- GPS1
- NME4
- VIM
- ACTC1
- TRIM35
- TP53
- CREBZF
- TOMM70
- CAPN1
disease
regulated by
- HNF4A
- Immunoglobulin
- DT-061
- GPR15LG
regulates
- COPB2
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CAPN8 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- proteolysis
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- Golgi apparatus
MOLECULAR FUNCTION
What the gene product does at the molecular level
- calcium ion binding
- calcium-dependent cysteine-type endopeptidase activity