FLT4 Gene Summary [Human]
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FLT4 |
| Official Name | fms related receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3767] |
| Ensembl ID | ENSG00000037280 |
| Bio databases IDs | |
| Aliases | fms related receptor tyrosine kinase 4, vascular endothelial growth factor receptor 3, VEGF receptor-3, Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4, primary congenital lymphedema |
| Synonyms | AI323512, CHTD7, Chy, FLT41, FMS-like tyrosine kinase 4, Fms related receptor tyrosine kinase 4, HEMC, LMPH1A, LMPHM1, LOC285682, PCL, VEGFR-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FLT4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine kinase
- Protein kinase domain
- VEGFR-2 Transmembrane domain
- ligand-binding domain
- Immunoglobulin like
- intracellular domain
- vascular endothelial growth factor receptor
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- growth factor binding
- VEGF-C/VEGF-D binding domain
- extracellular domain
- soluble domain
- Protein kinase (unclassified specificity)
- ligand-binding IG homology domain
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- protein phosphatase binding
- Immunoglobulin I-set domain
- protein binding
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- tyrosine kinase domain
- protein homodimerization
Pathways
Biological processes and signaling networks where the FLT4 gene in human plays a role, providing insight into its function and relevance in health or disease.
- CREB Signaling in Neurons
- eNOS Signaling
- FAK Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-15 Production
- IL-8 Signaling
- NF-κB Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- PTEN Signaling
- Role of Tissue Factor in Cancer
- Sperm Motility
- STAT3 Pathway
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastatic colon cancer
- advanced colon cancer
- advanced rectal cancer
- microsatellite instability high colon cancer
- metastatic rectal cancer
- colorectal cancer
- adenocarcinoma of the small bowel
- metastatic colorectal cancer
role in cell
- expression in
- proliferation
- quantity
- apoptosis
- cell death
- activation in
- phosphorylation in
- number
- growth
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- cytosol
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FLT4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- regulation of MAPK cascade
- positive regulation of protein kinase C signaling cascade
- multicellular organismal development
- positive regulation of cell proliferation
- sprouting angiogenesis
- blood vessel morphogenesis
- protein autophosphorylation
- lung alveolus development
- angiogenesis
- vasculature development
- lymph vessel development
- lymphangiogenesis
- positive regulation of kinase activity
- positive regulation of endothelial cell migration
- positive regulation vascular endothelial growth factor production
- vascular endothelial growth factor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- regulation of blood vessel remodeling
- respiratory system process
- vascular endothelial growth factor receptor signaling pathway
- negative regulation of apoptotic process
- positive regulation of JNK cascade
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cellular response to vascular endothelial growth factor stimulus
- positive regulation of endothelial cell proliferation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytosol
- receptor complex
- extracellular region
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- protein homodimerization activity
- protein phosphatase binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- vascular endothelial growth factor-activated receptor activity