THAP7 Gene Summary [Human]
Enables several functions, including C2H2 zinc finger domain binding activity; histone binding activity; and histone deacetylase binding activity. Involved in negative regulation of histone acetylation and negative regulation of transcription by RNA polymerase II. Located in nuclear membrane and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | THAP7 |
| Official Name | THAP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:23190] |
| Ensembl ID | ENSG00000184436 |
| Bio databases IDs | |
| Aliases | THAP domain containing 7 |
| Synonyms | 1810004B07RIK, THAP domain containing 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THAP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- protein binding activity, bridging
- THAP domain
- transcription factor binding
- histone deacetylase binding
- protein domain specific binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- intracellular membrane-bounded organelle
- nucleoplasm
- nuclear envelope
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THAP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- intracellular membrane-bounded organelle
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- DNA binding
- identical protein binding
- protein binding
- histone deacetylase binding
- histone binding
- metal ion binding
- methylated histone residue binding
- C2H2 zinc finger domain binding
- histone acetyl-lysine binding