PDIA2
PDIA2 Gene Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]
Details
| Type | Protein Coding |
| Official Symbol | PDIA2 |
| Official Name | protein disulfide isomerase family A member 2 [Source:HGNC Symbol;Acc:HGNC:14180] |
| Ensembl ID | ENSG00000185615 |
| Bio databases IDs | |
| Aliases | protein disulfide isomerase family A member 2 |
| Synonyms | 1810041F13RIK,PDA2,PDI,PDIP,Pdipl,PDIR,protein disulfide isomerase associated 2,protein disulfide isomerase family A member 2,protein disulfide isomerase family A, member 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Thioredoxin-like
- enzyme
- calcium binding loop
- protein binding
- thioredoxin
- disulfide oxidoreductase
- protein disulfide isomerase, eukaryotic
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- active site
- protein disulfide-isomerase domain
Pathways
Biological processes and signaling networks where the PDIA2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CUL3
- GRB2
- HM13
- KRTAP6-1
- HSPA5
- GAPDH
- MTTP
- PIK3R1
- ERO1A
- SNCA
disease
- hypertension
- diabetes mellitus
- lymphomagenesis
- gastric adenocarcinoma
- gastric epithelial cancer
- central nervous system cancer
- Waldenström macroglobulinemia
- primary central nervous system lymphoma
- primary cancer
- thrombosis
regulated by
- tunicamycin
- KRAS
- insulin
- trichostatin A
- tretinoin
- PABA/NO
- C3
- adenosine triphosphate
- calcimycin
- UCHL1
regulates
- F2
- AKT
- reactive oxygen species
- insulin
- proinsulin
- BAK1
- cyclic GMP
- RAC1
- INS
- VTN
role in cell
- apoptosis
- aggregation
- permeabilization
- migration
- binding
- oligomerization in
- retention in
- permeabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell surface
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum lumen
- microsome
- cis face of the Golgi apparatus
- rough endoplasmatic reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the PDIA2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein folding
- platelet aggregation
- response to endoplasmic reticulum stress
- protein retention in ER lumen
- protein folding in endoplasmic reticulum
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
MOLECULAR FUNCTION
What the gene product does at the molecular level
- disulfide oxidoreductase activity
- protein binding
- protein disulfide oxidoreductase activity
- protein disulfide isomerase activity
- steroid binding