PIK3R1 Gene Summary [Human]
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | PIK3R1 |
| Official Name | phosphoinositide-3-kinase regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:8979] |
| Ensembl ID | ENSG00000145675 |
| Bio databases IDs | |
| Aliases | phosphoinositide-3-kinase regulatory subunit 1, phosphoinositide-3-kinase regulatory subunit alpha |
| Synonyms | AA414921, AGM7, GRB1, IMD36, LOC105379008, p85, p85-alpha, p85alpha regulatory adapter, p85 subunit of PI3-kinase, P85 α, p85-α regulatory subunit of phosphatidylinositol 3-kinase, phosphatidylinositol 3-kinase p85-α regulatory subunit, phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 α), phosphoinositide-3-kinase regulatory subunit 1, PI3K, PI3KA, PI3KR1, PIK31R1, pp85, REGULATORY PI3K subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIK3R1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- proline-BCR-proline domain
- p110 binding domain
- insulin receptor binding
- protein binding activity, bridging
- phosphoprotein binding
- phosphoinositide 3-kinase regulator
- estrogen receptor binding
- RhoGAP
- GTPase-activator protein for Rho-like GTPases
- insulin-like growth factor receptor binding
- proline rich domain
- polypeptide hormone binding
- receptor tyrosine kinase binding
- Ras-binding domain
- alcohol group acceptor phosphotransferase
- Src homology 2 (SH2) domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- iSH2_PI3K_IA_R
- ubiquitin protein ligase binding
- phosphatidylinositol 3-kinase regulator
- lipid kinase
- protein kinase binding
- calmodulin binding
- protein phosphatase binding
- platelet-derived growth factor receptor binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
- phosphotyrosine binding
- protein domain specific binding
- protein binding
- receptor binding
- neurotrophin TRKA receptor binding
- phosphorylation site
- Src Homology 3 domain superfamily
- inter-SH2 domain
- kinase
- ATPase binding
- phosphoinositide 3-kinase binding
- kinase activator
- protein heterodimerization
Pathways
Biological processes and signaling networks where the PIK3R1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Angiopoietin Signaling
- Apelin Cardiomyocyte Signaling Pathway
- Cancer Drug Resistance By Drug Efflux
- CCR3 Signaling in Eosinophils
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- ErbB Signaling
- ErbB4 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- liver neoplasia
- epithelial neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- schizophrenia
- precursor B-cell acute lymphoblastic leukemia
role in cell
- expression in
- accumulation in
- formation
- formation in
- differentiation
- proliferation
- apoptosis
- quantity
- replication in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- high-density microsomal fractions
- soluble fraction
- low-density microsomal fraction
- intracellular space
- perinuclear region
- cellular membrane
- focal complexes
- Nucleus
- Plasma Membrane
- intercellular junctions
- immunological synapses
- cytosol
- cis Golgi networks
- cellular protrusions
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIK3R1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin receptor signaling pathway
- positive regulation of RNA splicing
- positive regulation of filopodium assembly
- phosphatidylinositol phosphorylation
- transcription from RNA polymerase II promoter
- induction of apoptosis via death domain receptors
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of smooth muscle cell proliferation
- cellular response to insulin stimulus
- protein kinase B signaling cascade
- immune response
- cytokine-mediated signaling pathway
- negative regulation of osteoclast differentiation
- cellular response to UV
- substrate adhesion-dependent cell spreading
- positive regulation of tumor necrosis factor production
- interleukin-18-mediated signaling pathway
- positive regulation of lamellipodium assembly
- growth hormone receptor signaling pathway
- positive regulation of protein import into nucleus
- B cell differentiation
- regulation of toll-like receptor 4 signaling pathway
- insulin-like growth factor receptor signaling pathway
- positive regulation of glucose import
- DNA damage response, signal transduction resulting in induction of apoptosis
- natural killer cell mediated cytotoxicity
- positive regulation of endoplasmic reticulum unfolded protein response
- T cell differentiation
- osteoclast differentiation
- positive regulation of leukocyte migration
- negative regulation of stress fiber assembly
- negative regulation of cell-matrix adhesion
- cellular glucose homeostasis
- protein import into nucleus
- negative regulation of apoptotic process
- protein stabilization
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
- phosphatidylinositol 3-kinase complex
- nucleus
- perinuclear region of cytoplasm
- cis-Golgi network
- cell-cell junction
- cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- kinase activator activity
- phosphatidylinositol 3-kinase binding
- insulin binding
- phosphatidylinositol 3-kinase regulator activity
- protein phosphatase binding
- ErbB-3 class receptor binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- insulin receptor binding
- 1-phosphatidylinositol-3-kinase regulator activity
- neurotrophin TRKA receptor binding
- insulin-like growth factor receptor binding
- phosphotyrosine binding
- phosphatidylinositol kinase activity
- protein binding
- protein heterodimerization activity
- insulin receptor substrate binding