TNFRSF4 Gene Summary [Human]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF4 |
| Official Name | TNF receptor superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:11918] |
| Ensembl ID | ENSG00000186827 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 4 |
| Synonyms | ACT35, CD134, IMD16, Ly-70, OX40, TNF receptor superfamily member 4, tumor necrosis factor receptor superfamily, member 4, tumour necrosis factor receptor superfamily, member 4, Txgp1, TXGP1L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- extracellular domain
- costimulatory domain
- tumor necrosis factor receptor
- intracellular domain
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Pathways
Biological processes and signaling networks where the TNFRSF4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- hyperplasia
- insulin-dependent diabetes mellitus
- non-insulin-dependent diabetes mellitus
- laryngeal squamous cell carcinoma
- melanoma cancer
- hypersensitivity reaction type I
- atopic dermatitis
- oropharyngeal squamous-cell carcinoma
role in cell
- expression in
- production in
- quantity
- proliferation
- growth
- activation in
- apoptosis
- accumulation
- survival
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- inflammatory response
- tumor necrosis factor-mediated signaling pathway
- immune response
- negative regulation of transcription, DNA-dependent
- T cell proliferation
- positive regulation of immunoglobulin production
- positive regulation of B cell proliferation
- negative regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor-activated receptor activity
- viral receptor activity