NANOS3 Gene Summary [Human]
Predicted to enable mRNA binding activity. Involved in germ cell development; negative regulation of translation; and positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | NANOS3 |
| Official Name | nanos C2HC-type zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:22048] |
| Ensembl ID | ENSG00000187556 |
| Bio databases IDs | |
| Aliases | nanos C2HC-type zinc finger 3 |
| Synonyms | NANOS1L, nanos C2HC-type zinc finger 3, NOS3, ZC2HC12C |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NANOS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- enzyme activator activity
- Nanos RNA binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NANOS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- germ cell development
- mRNA destabilization
- oogenesis
- spermatogenesis
- apoptotic signaling pathway
- regulation of cell cycle
- negative regulation of translation
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasmic stress granule
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- protein binding
- mRNA binding
- enzyme activator activity