COL14A1 Gene Summary [Human]
This gene encodes the alpha chain of type XIV collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XIV collagen interacts with the fibril surface and is involved in the regulation of fibrillogenesis. [provided by RefSeq, Jan 2013]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | COL14A1 |
| Official Name | collagen type XIV alpha 1 chain [Source:HGNC Symbol;Acc:HGNC:2191] |
| Ensembl ID | ENSG00000187955 |
| Bio databases IDs | |
| Aliases | collagen type XIV alpha 1 chain |
| Synonyms | 5730412L22Rik, COLLAGEN type XIV, collagen, type XIV, alpha 1, collagen type XIV alpha 1 chain, collagen, type XIV, α 1, collagen type XIV α 1 chain, Collagen XIV, UND |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COL14A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular matrix structural constituent conferring tensile strength
- von Willebrand factor (vWF) type A domain
- LamG
- FN3
- vWFA
- Collagen triple helix repeat (20 copies)
- von Willebrand factor type A domain
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- diabetic nephropathy
- Peyronie disease
- idiopathic pulmonary fibrosis
- diabetic foot ulcer disorder
- endometriosis
- ischemic stroke
- Dupuytren contracture
- gastritis
- burn
regulates
- lipid
- SLC2A4
role in cell
- growth
- proliferation
- diameter
- bundling
- clustering
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COL14A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular cardiac muscle tissue development
- homeostasis of number of cells within a tissue
- extracellular matrix organization
- regulation of cell growth involved in cardiac muscle cell development
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- interstitial matrix
- collagen
- collagen type XIV
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- RNA binding
- collagen binding
- extracellular matrix structural constituent conferring tensile strength
- protein binding, bridging
- extracellular matrix structural constituent