IL31 Gene Summary [Human]
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL31 |
| Official Name | interleukin 31 [Source:HGNC Symbol;Acc:HGNC:19372] |
| Ensembl ID | ENSG00000204671 |
| Bio databases IDs | |
| Aliases | interleukin 31 |
| Synonyms | 1700013B14RIK, AABR07036324.1, interleukin 31 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- Interleukin 31
- protein binding
- oncostatin-M receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the IL31 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- pruritus
- systemic sclerosis
- dermatitis
- spontaneous dermatitis
- psoriasis
- allergic contact dermatitis
role in cell
- production in
- activation in
- expression in
- proliferation
- differentiation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- immune system process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- cytokine receptor binding