SLC2A13 Gene Summary [Human]
Enables ATPase binding activity; myo-inositol:proton symporter activity; and protease binding activity. Involved in myo-inositol transport and positive regulation of amyloid-beta formation. Is integral component of plasma membrane. Part of cell body; cell periphery; and cell projection. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC2A13 |
| Official Name | solute carrier family 2 member 13 [Source:HGNC Symbol;Acc:HGNC:15956] |
| Ensembl ID | ENSG00000151229 |
| Bio databases IDs | |
| Aliases | solute carrier family 2 member 13, H(+)-myo-inositol symporter |
| Synonyms | 6530403A04, A630029G22, A630029G22Rik, AI505012, GLUT13, Gm308, HMIT, solute carrier family 2 (facilitated glucose transporter), member 13, solute carrier family 2 member 13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC2A13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- benzoate transport
- protease binding
- myo-inositol:hydrogen symporter
- Sugar (and other) transporter
- MFS transporter, sugar porter (SP) family
- myo-inositol transporter
- Major Facilitator Superfamily
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- insomnia
- Parkinson disease
- overall survival
- leprosy
- benign urinary system neoplasm
- benign neoplasia
- inflammatory bowel disease
- productive infection by HIV-1
regulates
- myo-inositol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell periphery
- intracellular space
- cellular membrane
- growth cone
- cellular protrusions
- perikaryon
- astrocyte projections
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC2A13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- myo-inositol transport
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- organelle membrane
- cell projection
- plasma membrane
- lysosome
- growth cone
- early endosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cell body
- apical plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein binding
- myo-inositol transmembrane transporter activity
- protease binding
- myo-inositol:hydrogen symporter activity
- ATPase binding