DUSP21 Gene Summary [Human]

This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]

Details

Type
Protein Coding
Official Symbol
DUSP21
Official Name
dual specificity phosphatase 21 [Source:HGNC Symbol;Acc:HGNC:20476]
Ensembl ID
ENSG00000189037
Bio databases IDs NCBI: 63904 Ensembl: ENSG00000189037
Aliases dual specificity phosphatase 21
Synonyms 1700094E07Rik, DSP21, dual specificity phosphatase 21, LMWDSP21, RGD1560427
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUSP21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Dual specificity phosphatase, catalytic domain
  • protein-tyrosine-phoshatase
  • protein phosphatase
  • phosphatase
  • protein binding
  • PTP_DSP_cys

Pathways

Biological processes and signaling networks where the DUSP21 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
role in cell
  • motility

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cellular membrane
  • Nucleus
  • Mitochondria
  • mitochondrial matrix
  • mitochondrial intermembrane space
  • mitochondrial inner membrane
  • sperm tail

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human DUSP21 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • peptidyl-tyrosine dephosphorylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • mitochondrial matrix
  • cytoplasm
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • protein tyrosine phosphatase activity
  • MAP kinase tyrosine/serine/threonine phosphatase activity
  • myosin phosphatase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.