Dusp21 Gene Summary [Mouse]
Enables phosphoprotein phosphatase activity. Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human DUSP21 (dual specificity phosphatase 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp21 |
| Official Name | dual specificity phosphatase 21 [Source:MGI Symbol;Acc:MGI:1920797] |
| Ensembl ID | ENSMUSG00000025043 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 21 |
| Synonyms | 1700094E07Rik, DSP21, dual specificity phosphatase 21, LMWDSP21, RGD1560427 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- protein-tyrosine-phoshatase
- protein phosphatase
- phosphatase
- protein binding
- PTP_DSP_cys
Pathways
Biological processes and signaling networks where the Dusp21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial inner membrane
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- cytoplasm
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity