RCN1 Gene Summary [Human]
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | RCN1 |
| Official Name | reticulocalbin 1 [Source:HGNC Symbol;Acc:HGNC:9934] |
| Ensembl ID | ENSG00000049449 |
| Bio databases IDs | |
| Aliases | reticulocalbin 1, proliferation-inducing gene 20 |
| Synonyms | HEL-S-84, PIG20, RCAL, RCN, Reticulocalbin 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RCN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- calcium ion binding
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- rectal adenocarcinoma
- colon adenocarcinoma
- epithelial cancer
- colorectal carcinomagenesis
- rectum cancer
- colon epithelial cancer
- rectosigmoid adenocarcinoma
- colorectal cancer distal to the spelic flexure
- cecum adenocarcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RCN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- camera-type eye development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding