RRP7A Gene Summary [Human]
Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of CURI complex and UTP-C complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RRP7A |
| Official Name | ribosomal RNA processing 7 homolog A [Source:HGNC Symbol;Acc:HGNC:24286] |
| Ensembl ID | ENSG00000189306 |
| Bio databases IDs | |
| Aliases | ribosomal RNA processing 7 homolog A |
| Synonyms | 1110014J01Rik, BK126B4.3, CGI-96, Kheg1, MCPH28, RGD1311547, ribosomal RNA processing 7 homolog A, Rrp7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRP7A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RRP7_like
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- pre-ribosome
- cilia
- centrosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRP7A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- blastocyst formation
- ribosome biogenesis
- ribosomal small subunit assembly
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- centrosome
- cytoplasm
- cilium
- UTP-C complex
- nucleolus
- CURI complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding