Rrp7a Gene Summary [Mouse]
Predicted to enable RNA binding activity. Acts upstream of or within blastocyst formation. Located in cytoplasm. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 28. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rrp7a |
| Official Name | ribosomal RNA processing 7 homolog A [Source:MGI Symbol;Acc:MGI:1922028] |
| Ensembl ID | ENSMUSG00000018040 |
| Bio databases IDs | |
| Aliases | ribosomal RNA processing 7 homolog A |
| Synonyms | 1110014J01Rik, BK126B4.3, CGI-96, Kheg1, MCPH28, RGD1311547, ribosomal RNA processing 7 homolog A, Rrp7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rrp7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RRP7_like
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- pre-ribosome
- cilia
- centrosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rrp7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal small subunit biogenesis
- blastocyst formation
- ribosome biogenesis
- ribosomal small subunit assembly
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- centrosome
- cytoplasm
- cilium
- UTP-C complex
- nucleolus
- CURI complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding