PRTN3 Gene Summary [Human]
Enables enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; membrane protein ectodomain proteolysis; and neutrophil extravasation. Located in azurophil granule lumen; cytosol; and plasma membrane raft. Colocalizes with plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PRTN3 |
| Official Name | proteinase 3 [Source:HGNC Symbol;Acc:HGNC:9495] |
| Ensembl ID | ENSG00000196415 |
| Bio databases IDs | |
| Aliases | proteinase 3, myeloblastin, serine proteinase, neutrophil, Wegener granulomatosis autoantigen |
| Synonyms | ACPA, AGP7, C-ANCA, MBN, MBT, mPR3, NP-4, P29, PR-3, proteinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRTN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- catalytic domain
- peptidase
- enzyme binding
- Domain of unknown function (DUF1986)
- protein binding
- receptor binding
- myeloblastin
Pathways
Biological processes and signaling networks where the PRTN3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- chronic obstructive pulmonary disease
- myopia
- hyperplasia
- stroke
- Wegener granulomatosis
- cystic fibrosis
- IgA nephropathy
- inflammatory disorder
- renal failure
role in cell
- cell viability
- expression in
- accumulation in
- apoptosis
- number
- quantity
- growth
- killing
- cell death
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- primary granule fractions
- extracellular trap
- intracellular membrane-bounded organelle
- azurophil granule lumen
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- lysosome
- cytosol
- secretory vesicles
- azurophil granules
- specific granules
- membrane rafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRTN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane protein ectodomain proteolysis
- mature dendritic cell differentiation
- positive regulation of cell proliferation
- proteolysis
- neutrophil extravasation
- collagen catabolic process
- antimicrobial humoral response
- positive regulation of GTPase activity
- negative regulation of phagocytosis
- cell-cell junction maintenance
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- cytosol
- extracellular region
- azurophil granule lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- serine-type endopeptidase activity
- receptor binding
- enzyme binding