PI3 Gene Summary [Human]
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | PI3 |
| Official Name | peptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:8947] |
| Ensembl ID | ENSG00000124102 |
| Bio databases IDs | |
| Aliases | peptidase inhibitor 3, skin-derived antileukoproteinase, trappin-2 |
| Synonyms | cementoin, Elafin, ESI, peptidase inhibitor 3, SKALP, tiprelestat, WAP3, WFDC14 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PI3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WAP
- endopeptidase inhibitor
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
- serine protease inhibitor activity
- structural constituent of epidermis
- Trappin protein transglutaminase binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- Crohn disease
- uterine serous papillary cancer
- breast carcinoma
- organismal death
- plaque psoriasis
- delayed hypersensitive reaction
- prostate cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- apoptosis
- migration
- growth
- proliferation
- expression in
- number
- quantity
- inhibition in
- cell cycle progression
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cornified envelope
- cytosol
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PI3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- copulation
- antibacterial humoral response
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cornified envelope
- cytosol
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- structural constituent of epidermis
- endopeptidase inhibitor activity