AJAP1 Gene Summary [Human]
Enables beta-catenin binding activity. Involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Located in several cellular components, including adherens junction; basolateral plasma membrane; and cell-cell contact zone. Is spanning component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | AJAP1 |
| Official Name | adherens junctions associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30801] |
| Ensembl ID | ENSG00000196581 |
| Bio databases IDs | |
| Aliases | adherens junctions associated protein 1, transmembrane protein SHREW1 |
| Synonyms | adherens junction associated protein 1, adherens junctions associated protein 1, Gm573, MOT8, neumo48, SHREW-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AJAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- cytoplasmic domain
- beta-catenin binding
- AJAP1/PANP C-terminus
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intercellular junctions
- cytoplasmic face of plasma membrane
- basolateral membrane
- lateral plasma membrane
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AJAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- negative regulation of cell-matrix adhesion
- cell adhesion
- regulation of polarized epithelial cell differentiation
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- adherens junction
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
- cell surface
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-catenin binding