Ajap1 Gene Summary [Mouse]
Enables protein domain specific binding activity. Predicted to be involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Predicted to be located in basolateral plasma membrane and cell surface. Predicted to be active in adherens junction; cell-cell contact zone; and cytoplasmic side of plasma membrane. Is expressed in several structures, including adrenal gland; brain; eye; genitourinary system; and spinal cord. Orthologous to human AJAP1 (adherens junctions associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ajap1 |
| Official Name | adherens junction associated protein 1 [Source:MGI Symbol;Acc:MGI:2685419] |
| Ensembl ID | ENSMUSG00000039546 |
| Bio databases IDs | |
| Aliases | adherens junction associated protein 1 |
| Synonyms | adherens junction associated protein 1, adherens junctions associated protein 1, Gm573, MOT8, neumo48, SHREW-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ajap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- cytoplasmic domain
- beta-catenin binding
- AJAP1/PANP C-terminus
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intercellular junctions
- cytoplasmic face of plasma membrane
- basolateral membrane
- lateral plasma membrane
- anchoring junction
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ajap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of wound healing
- negative regulation of cell-matrix adhesion
- cell adhesion
- regulation of polarized epithelial cell differentiation
Cellular Component
Where in the cell the gene product is active
- cell-cell contact zone
- adherens junction
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
- cell surface
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-catenin binding