UGT2B15 Gene Summary [Human]
This gene encodes a glycosyltransferase that is invovled in the metabolism and elimination of toxic compounts, both endogenous and of xenobiotic origin. This gene plays a role in the regulation of estrogens and androgens. This locus is present in a cluster of similar genes and pseudogenes on chromosome 4. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | UGT2B15 |
| Official Name | UDP glucuronosyltransferase family 2 member B15 [Source:HGNC Symbol;Acc:HGNC:12546] |
| Ensembl ID | ENSG00000196620 |
| Bio databases IDs | |
| Aliases | UDP glucuronosyltransferase family 2 member B15 |
| Synonyms | HLUG4, LOC728160, UDP glucuronosyltransferase family 2 member B15, UDPGT2B15, UDPGT 2B8, UDPGTh-3, UGT2B8 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UGT2B15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- glycosyltransferase, MGT family
- enzyme
- UDP-glucoronosyl and UDP-glucosyl transferase
- glucuronosyltransferase
Pathways
Biological processes and signaling networks where the UGT2B15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial cancer
- liver cancer
- Laron syndrome
- hepatitis B virus-related hepatocellular carcinoma
- progressive familial intrahepatic cholestasis type 1
role in cell
- expression in
- proliferation
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UGT2B15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen metabolic process
- cellular glucuronidation
- xenobiotic metabolic process
- steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- glucuronosyltransferase activity