KRT35
KRT35 Gene Summary
The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KRT35 |
| Official Name | keratin 35 [Source:HGNC Symbol;Acc:HGNC:6453] |
| Ensembl ID | ENSG00000197079 |
| Bio databases IDs | |
| Aliases | keratin 35, hard keratin type I 5 |
| Synonyms | HA5,hHa5,K35,Ka30,keratin 35,Krt1-2,Krt1-24,KRTHA5 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the KRT35 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TXLNB
- KRT1
- HOXC13
- DLG3
- GRB2
- HCK
- RAF1
- MCRS1
- POU4F2
- CFTR
disease
- androgenic alopecia
- squamous-cell carcinoma
- squamous cell cancer
regulated by
- tetradecanoylphorbol acetate
- PLA2G10
- Gstp1 (includes others)
- TRH
- p30II
- PPARG
- HOXC13
- KAT5
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KRT35 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- epithelial cell differentiation
- anatomical structure morphogenesis
- intermediate filament organization
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- cytoskeleton
- extracellular vesicular exosome
- cytosol
- intermediate filament
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- structural molecule activity