HCK
HCK Gene Summary
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | HCK |
| Official Name | HCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4840] |
| Ensembl ID | ENSG00000101336 |
| Bio databases IDs | |
| Aliases | HCK proto-oncogene, Src family tyrosine kinase |
| Synonyms | AIPCV,AURA13,Bmk,haemopoietic cell kinase,HCK proto-oncogene, Src family tyrosine kinase,Hctk,hematopoietic cell kinase,hemopoietic cell kinase,JTK9,p56Hck,p59Hck,P61HCK |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SH4 domain
- Protein kinase (unclassified specificity)
- lipid binding
- catalytic domain
- ATP-binding domain
- Protein tyrosine and serine/threonine kinase
- phosphotyrosine binding
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- unique protein domain
- Src Homology 3 domain superfamily
- kinase
- SH2-catalytic domain linker
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Src homology 2 (SH2) domain
- tail domain
- Tyrosine kinase, catalytic domain
- myristoylation site
Pathways
Biological processes and signaling networks where the HCK gene plays a role, providing insight into its function and relevance in health or disease.
- Chronic Myeloid Leukemia Signaling
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Ephrin A Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- GM-CSF Signaling
- Gαs Signaling
- HER-2 Signaling in Breast Cancer
- IL-15 Production
- Opioid Signaling Pathway
- Phagosome Formation
- Reelin Signaling in Neurons
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Sperm Motility
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- AR
- HSP90AB1
- PAK2
- MDM2
- YAP1
- WFS1
- BCAR1
- MTUS2
- KHDRBS1
- LMNA
disease
- infection
- precursor B-cell acute lymphoblastic leukemia
- autoinflammation with pulmonary and cutaneous vasculitis
- mixed neoplasm with eosinophilia
- blistering
- hypoplasia
- chronic phase chronic myeloid leukemia
- neoplastic cell transformation
- chronic myeloid leukemia
- accelerated phase chronic myelogenous leukemia
regulated by
- hydrogen peroxide
- HCK
- CBL
- IL2
- MYD88
- beta-estradiol
- IL4
- PP2/AG1879 tyrosine kinase inhibitor
- tretinoin
- IFNG
regulates
- MAPK8
- p38 MAPK
- Ap1
- reactive oxygen species
- SRC
- NFkB (complex)
- IL6
- Ca2+
- IL1B
- TNF
role in cell
- survival
- apoptosis
- cell viability
- cytotoxicity
- production in
- expression in
- hypertrophy
- phosphorylation in
- cellular infiltration by
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- podosome rosette
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- lysosome
- Golgi Apparatus
- actin filaments
- cytosol
- cytoplasmic face of plasma membrane
- caveolae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the HCK gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell shape
- respiratory burst after phagocytosis
- peptidyl-tyrosine phosphorylation
- positive regulation of cell proliferation
- mesoderm development
- protein autophosphorylation
- cell adhesion
- Fc-gamma receptor signaling pathway involved in phagocytosis
- protein phosphorylation
- regulation of sequence-specific DNA binding transcription factor activity
- integrin-mediated signaling pathway
- inflammatory response
- cytokine-mediated signaling pathway
- innate immune response-activating signal transduction
- intracellular signal transduction
- interferon-gamma-mediated signaling pathway
- leukocyte degranulation
- transmembrane receptor protein tyrosine kinase signaling pathway
- negative regulation of inflammatory response to antigenic stimulus
- leukocyte migration involved in immune response
- regulation of actin cytoskeleton organization
- innate immune response
- negative regulation of apoptotic process
- positive regulation of actin filament polymerization
- cell differentiation
- lipopolysaccharide-mediated signaling pathway
- regulation of inflammatory response
- regulation of phagocytosis
- regulation of podosome assembly
CELLULAR COMPONENT
Where in the cell the gene product is active
- Golgi apparatus
- actin filament
- cell projection
- plasma membrane
- internal side of plasma membrane
- lysosome
- nucleus
- caveola
- focal adhesion
- intracellular membrane-bounded organelle
- cytosol
- transport vesicle
MOLECULAR FUNCTION
What the gene product does at the molecular level
- phosphotyrosine binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- lipid binding
- receptor binding