SLC28A3 Gene Summary [Human]
Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | SLC28A3 |
| Official Name | solute carrier family 28 member 3 [Source:HGNC Symbol;Acc:HGNC:16484] |
| Ensembl ID | ENSG00000197506 |
| Bio databases IDs | |
| Aliases | solute carrier family 28 member 3 |
| Synonyms | CIB, CNT3, solute carrier family 28 member 3, solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC28A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine transporter
- nucleoside transporter
- Nucleoside recognition
- pyrimidine- and adenine-specific:sodium symporter
- intracellular domain
- purine-specific nucleoside:sodium symporter
- protein binding
- Na+ dependent nucleoside transporter C-terminus
- Na+ dependent nucleoside transporter N-terminus
- transporter
- nucleoside:sodium symporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- attention deficit hyperactivity disorder
- spontaneous preterm birth
regulates
- thymidine
- purine nucleoside
- alovudine
- pyrimidine nucleoside
- cytidine
- uridine
- pyrimidine base
- 6-mercaptopurine
- adenosine
- xenobiotic
role in cell
- cell death
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC28A3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- uridine transport
- drug transmembrane transport
- purine nucleoside transport
- pyrimidine-containing compound transmembrane transport
- xenobiotic metabolic process
- sodium ion transmembrane transport
- pyrimidine base transport
- pyrimidine nucleoside transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- brush border membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleoside:sodium symporter activity
- uridine transmembrane transporter activity
- pyrimidine- and adenine-specific:sodium symporter activity
- protein binding
- purine-specific nucleoside:sodium symporter activity
- purine base transmembrane transporter activity