IGKC Gene Summary [Human]
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in retina homeostasis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | IGKC |
| Official Name | immunoglobulin kappa constant [Source:HGNC Symbol;Acc:HGNC:5716] |
| Ensembl ID | ENSG00000211592 |
| Bio databases IDs | |
| Aliases | immunoglobulin kappa constant |
| Synonyms | HCAK1, IgG κ, IG KAPPA CONSTANT, Ig kappa light chain, IGKCD, IG LIGHT CHAIN K, IG κ CONSTANT, Ig κ light chain, immunoglobulin kappa constant, immunoglobulin κ constant, Immunoglobulin κ Light Chain, Kappa Light Chain, Km, κ Light Chain |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGKC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- complementarity-determining region
- constant light chain domain
- antigen binding domain
- signal peptide
Pathways
Biological processes and signaling networks where the IGKC gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- FcγRIIB Signaling in B Lymphocytes
- IL-12 Signaling and Production in Macrophages
- IL-15 Signaling
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- contact dermatitis
- rheumatoid arthritis
- psoriatic arthritis
- eosinophilic esophagitis
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- hypoplasia
- Alzheimer disease
- prostate cancer
role in cell
- production in
- expression in
- proliferation
- number
- abnormal morphology
- quantity
- lack
- differentiation
- abnormal number
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- Plasma Membrane
- exosomes
- plasma
- basement membrane
- glomerular basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGKC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- immunoglobulin mediated immune response
- adaptive immune response
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- IgD immunoglobulin complex
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- IgM immunoglobulin complex
- IgE immunoglobulin complex
- extracellular region
- IgA immunoglobulin complex
- plasma membrane
- IgG immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- antigen binding