Slc28a3 Gene Summary [Mouse]
Enables purine-specific nucleoside:sodium symporter activity and pyrimidine- and adenosine-specific:sodium symporter activity. Acts upstream of or within purine nucleoside transmembrane transport and pyrimidine nucleoside transport. Located in brush border membrane. Is expressed in pancreas. Orthologous to human SLC28A3 (solute carrier family 28 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Slc28a3 |
| Official Name | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 [Source:MGI Symbol;Acc:MGI:2137361] |
| Ensembl ID | ENSMUSG00000021553 |
| Bio databases IDs | |
| Aliases | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 |
| Synonyms | CIB, CNT3, solute carrier family 28 member 3, solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc28a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uridine transporter
- nucleoside transporter
- Nucleoside recognition
- pyrimidine- and adenine-specific:sodium symporter
- intracellular domain
- purine-specific nucleoside:sodium symporter
- protein binding
- Na+ dependent nucleoside transporter C-terminus
- Na+ dependent nucleoside transporter N-terminus
- transporter
- nucleoside:sodium symporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- attention deficit hyperactivity disorder
- spontaneous preterm birth
regulates
- thymidine
- purine nucleoside
- alovudine
- pyrimidine nucleoside
- cytidine
- uridine
- pyrimidine base
- 6-mercaptopurine
- adenosine
- xenobiotic
role in cell
- cell death
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc28a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- uridine transport
- drug transmembrane transport
- purine nucleoside transport
- pyrimidine-containing compound transmembrane transport
- xenobiotic metabolic process
- sodium ion transmembrane transport
- pyrimidine base transport
- pyrimidine nucleoside transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- brush border membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleoside:sodium symporter activity
- uridine transmembrane transporter activity
- pyrimidine- and adenine-specific:sodium symporter activity
- protein binding
- purine-specific nucleoside:sodium symporter activity
- purine base transmembrane transporter activity