ENTPD6 Gene Summary [Human]
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | ENTPD6 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 6 [Source:HGNC Symbol;Acc:HGNC:3368] |
| Ensembl ID | ENSG00000197586 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 6 |
| Synonyms | 2700026H11RIK, CD39L2, dJ738P15.3, ectonucleoside triphosphate diphosphohydrolase 6, IL-6SAG, IL6ST2, NTPDase-6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ENTPD6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- guanosine-diphosphatase
- nucleoside-diphosphatase
- uridine diphosphatase
- enzyme
- ASKHA_ATPase-like
- guanosine-5'-triphosphate,3'-diphosphate diphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell surface
- Extracellular Space
- Plasma Membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ENTPD6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- response to calcium ion
- response to magnesium ion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- Golgi membrane
- Golgi apparatus
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- nucleoside-diphosphatase activity
- nucleoside-triphosphatase activity
- guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity