Parva Gene Summary [Mouse]
Enables actin binding activity. Involved in several processes, including circulatory system development; smooth muscle cell chemotaxis; and substrate adhesion-dependent cell spreading. Acts upstream of or within cell adhesion. Located in several cellular components, including focal adhesion; lamellipodium; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PARVA (parvin alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parva |
| Official Name | parvin, alpha [Source:MGI Symbol;Acc:MGI:1931144] |
| Ensembl ID | ENSMUSG00000030770 |
| Bio databases IDs | |
| Aliases | parvin, alpha |
| Synonyms | 2010012A22Rik, 5430400F08Rik, Actopaxin, Actp, alpha PARVIN, CH-ILKBP, MXRA2, Parvin, Parvin alpha, parvin, alpha, Parvin α, parvin, α, α PARVIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Parva often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline-directed serine phosphorylation site
- binding protein
- protein kinase inhibitor activity
- actin binding
- paxillin-binding domain
- calponin homology (CH) domain superfamily
- protein binding
- phosphorylation site
Pathways
Biological processes and signaling networks where the Parva gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- asthma
- open-angle glaucoma
- organismal death
- congenital anomaly of cardiovascular system
- male pattern hair loss
- productive infection by HIV-1
role in cell
- adhesion
- apoptosis
- binding
- formation
- migration
- formation in
- phosphorylation in
- assembly
- cell spreading
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- caveolae-derived endocytic vesicles
- cytoskeleton
- perinuclear region
- focal complexes
- focal adhesions
- actin cytoskeleton
- Nucleus
- cytosol
- actin stress fibers
- cell-cell adherens junctions
- lamellipodia
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Parva gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- outflow tract septum morphogenesis
- smooth muscle cell chemotaxis
- cilium morphogenesis
- actin-mediated cell contraction
- establishment or maintenance of cell polarity
- sprouting angiogenesis
- substrate adhesion-dependent cell spreading
- heterotypic cell-cell adhesion
- protein stabilization
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- focal adhesion
- cytoplasm
- actin cytoskeleton
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- protein kinase inhibitor activity