COMP Gene Summary [Human]
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | COMP |
| Official Name | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] |
| Ensembl ID | ENSG00000105664 |
| Bio databases IDs | |
| Aliases | cartilage oligomeric matrix protein, thrombospondin-5 |
| Synonyms | cartilage oligomeric matrix protein, CTS2, EDM1, EPD1, MED, PSACH, THBS5, TSP-5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human COMP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- type III repeat domain
- cytokine binding
- vitamin D binding
- protease binding
- globular domain
- calcium ion binding
- extracellular matrix structural constituent
- coiled-coil domain
- protein binding
- fibronectin binding
- EGF-like domain
- EGF_CA
- thrombospondin type 3 repeat
- Thrombospondin C-terminal region
- Coiled coil region of thrombospondin
- binding protein
- integrin binding
- collagen binding
- EGF domain
- EGF repeat domain
- loop domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- non-small cell lung cancer
- pseudoachondroplasia
- gastric adenocarcinoma
- lung adenocarcinoma
- hypertrophic scarring
- severe multiple epiphyseal dysplasia 1
- non-small cell lung carcinoma
- rheumatoid arthritis
role in cell
- proliferation
- expression in
- apoptosis
- cell viability
- migration
- production in
- organization
- attachment
- aggregation
- angiogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- interterritorial matrix
- Cytoplasm
- cell-associated matrix
- cell surface
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- extracellular matrix
- plasma
- territorial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human COMP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- cellular senescence
- chondrocyte development
- response to unfolded protein
- skin development
- skeletal system development
- BMP signaling pathway
- apoptotic process
- platelet aggregation
- regulation of bone mineralization
- bone mineralization
- limb development
- negative regulation of hemostasis
- protein homooligomerization
- artery morphogenesis
- protein secretion
- vascular smooth muscle cell development
- organ morphogenesis
- musculoskeletal movement
- vascular smooth muscle contraction
- growth plate cartilage development
- negative regulation of apoptotic process
- regulation of gene expression
- chondrocyte proliferation
- protein processing
- tendon development
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- macromolecular complex
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- BMP binding
- protein binding
- collagen binding
- proteoglycan binding
- calcium ion binding
- heparan sulfate proteoglycan binding
- heparin binding
- protease binding
- integrin binding
- extracellular matrix structural constituent