KIF13B Gene Summary [Human]
Enables 14-3-3 protein binding activity and protein kinase binding activity. Involved in regulation of axonogenesis. Located in axon and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | KIF13B |
| Official Name | kinesin family member 13B [Source:HGNC Symbol;Acc:HGNC:14405] |
| Ensembl ID | ENSG00000197892 |
| Bio databases IDs | |
| Aliases | kinesin family member 13B, guanylate kinase associated kinesin |
| Synonyms | 5330429L19RIK, 6030414C01, C130021D12RIK, GAKIN, kinesin family member 13B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF13B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin protein 1B
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- protein kinase binding
- Myosin and Kinesin motor domain
- MAPK-interacting and spindle-stabilising protein-like
- CAP-Gly domain
- protein binding
- motor domain
- Kinesin-associated
- forkhead associated (FHA) domain superfamily
- Kinesin motor, catalytic domain
- microtubule binding
- FHA domain
- Kinesin motor domain
- guanylate kinase-like domain
- Domain of unknown function (DUF4045)
- CAP_GLY
- Sine oculis-binding protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heat hyperalgesia
role in cell
- binding in
- quantity
- movement by
- branching in
- branching
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- axon component
- Plasma Membrane
- vesicles
- cytosol
- sinusoidal membrane
- microvilli
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF13B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- cytoskeleton-dependent intracellular transport
- regulation of axonogenesis
- signal transduction
- T cell activation
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- kinesin complex
- axon
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein kinase binding
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding
- 14-3-3 protein binding