FBXO42 Gene Summary [Human]
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | FBXO42 |
| Official Name | F-box protein 42 [Source:HGNC Symbol;Acc:HGNC:29249] |
| Ensembl ID | ENSG00000037637 |
| Bio databases IDs | |
| Aliases | F-box protein 42 |
| Synonyms | 6720460I06Rik, Bc058667, F-box protein 42, Fbx42, JFK, KIAA1332, mKIAA1332 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXO42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- F-box domain
- Kelch motif
- F-box domain superfamily
- F-box
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- nonalcoholic fatty liver disease
- obesity
- ductal breast carcinoma
- ductal breast cancer
role in cell
- expression in
- phosphorylation in
- degradation in
- BI-2536 sensitivity
- angiogenesis by
- ubiquitination in
- mitotic defect
- TAK-901 sensitivity
- camptothecin resistance
- beta-oxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXO42 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding