CLEC4C Gene Summary [Human]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLEC4C |
| Official Name | C-type lectin domain family 4 member C [Source:HGNC Symbol;Acc:HGNC:13258] |
| Ensembl ID | ENSG00000198178 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4 member C |
| Synonyms | BDCA-2, CD303, CLEC4B, CLECSF11, CLECSF7, C-type lectin domain family 4 member C, Dendritic lectin, DLEC, HECL, PRO34150 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC4C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic cutaneous lupus erythematosus
- subacute cutaneous lupus erythematosus
- diabetic nephropathy
- systemic lupus erythematosus
- acute myeloid leukemia
- blastic plasmacytoid dendritic cell neoplasm
- hematologic cancer
- myeloid neoplasia
role in cell
- expression in
- phosphorylation in
- production in
- internalization in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC4C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adaptive immune response
Cellular Component
Where in the cell the gene product is active
- secretory granule membrane
- external side of plasma membrane
- tertiary granule membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- carbohydrate binding